The gallery programme began in 1984 in a Victorian terraced house in London’s East End. Initially named Interim Art, the gallery changed its name to Maureen Paley in 2004 as a celebration of its 20th anniversary. Since September 1999 the gallery has been situated in Bethnal Green, and in September 2020 relocated to Three Colts Lane.
In July 2017 Maureen Paley opened a second space in Hove called Morena di Luna. In October 2020 a third space was opened in Shoreditch, London called Studio M. From its inception, the gallery’s aim has remained consistent: to promote great and innovative artists in all media.